Metabolism/excretion: It truly is metabolized to norhydrocodone by cytochrome P450 3A4 and to hydromorphone, also biologically Energetic, by cytochrome P450 2D6.Opioid cross-reactivity is the uncommon prevalence of having an allergic reaction to multiple opioid.Hydrocodone can also be used to treat reasonable to significant pain caused by a Continu